Since then, the now 48-year-old American actress has had a whirlwind career, including her brush with the law in 2001 when she was arrested for shoplifting and became something of a recluse.
But Winona staged her comeback in 2006 with A Scanner Darkly, going on to land the role of single mother Joyce Byers in 2016's Netflix hit Stranger Things.
Recently, the star shocked fans with a throwback picture of her face in the
test shots for Stranger Things.
Fans of the show couldn't get over how different she looked with slicked back hair and barely any makeup - a far cry from her normal on-screen look as Joyce.
"I believe that Winona may have recently undergone the non-surgical treatment of fillers to her lips as she appears to have fuller lips compared to previous images – especially when smiling," they said.
"The provider has ensured
her lips still appear natural and in proportion to her facial
features.
"The average cost of lip fillers in the UK can range depending
on the provider and the amount of filler used, however, you can expect to
pay anything from £200 to £1,000 per treatment.
"I would also
suggest Winona has had anti-wrinkle injections, often referred to as Botox,
to her forehead de ella and around her eyes de ella (crow's feet). This
non-surgical treatment will create a smooth forehead and limit any frown or
expression lines.
"The treatment will normally last three to six months as muscle
action gradually returns and the lines and wrinkles begin to reappear. This
procedure can give the appearance of smoother skin if the patient desires a
more youthful appearance, or it can be used as a preventative measure to
slow the process of getting wrinkles."